One of my good friends Carrie is due with her first baby in less than two weeks. I was visiting her in Minnesota last week when she told me about a fabulous tip she had gotten from one of her mommy friends.
Layer a mattress pad and sheet on top of another mattress pad and sheet in your baby's crib. This way, when your baby has "blow out" (her description not mine!) in the middle of the night you can just remove the top sheet and mattress pad and the second sheet and mattress pad will already be on the bed!
For tired moms, this seems like a great trick! You won't need to worry about making a bed in the middle of the night and you can worry about washing the other set in the morning.